Pamela J McLean Selected Research

Proteostasis Deficiencies

1/2016	The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity.
5/2015	Targeting α-synuclein oligomers by protein-fragment complementation for drug discovery in synucleinopathies.
10/2014	Alpha-synuclein and tau: teammates in neurodegeneration?

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Pamela J McLean Research Topics

Disease

63	Parkinson Disease (Parkinson's Disease) 06/2022 - 05/2002
22	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 06/2004
22	Dementia (Dementias) 01/2020 - 06/2004
17	Synucleinopathies 01/2020 - 04/2008
8	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 08/2005
4	Lewy Body Disease (Lewy Body Dementia) 01/2022 - 12/2015
3	Multiple System Atrophy 01/2019 - 01/2010
3	Proteostasis Deficiencies 01/2016 - 10/2014
2	Rupture 01/2021 - 01/2017
2	Gliosis 01/2020 - 05/2013
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2016 - 03/2011
2	Amyloid Plaque 08/2011 - 08/2005
2	Huntington Disease (Huntington's Disease) 12/2006 - 03/2006
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2021
1	Inflammation (Inflammations) 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2020
1	Disease Progression 01/2019
1	Neuroinflammatory Diseases 03/2018
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 12/2015
1	Tauopathies 10/2014
1	Weight Loss (Weight Reduction) 01/2014
1	Parkinsonian Disorders (Parkinsonism) 01/2014
1	Gaucher Disease (Gaucher's Disease) 07/2011
1	Neuroblastoma 04/2006

Drug/Important Bio-Agent (IBA)

38	alpha-SynucleinIBA 01/2020 - 11/2002
27	SynucleinsIBA 01/2022 - 05/2002
21	Proteins (Proteins, Gene)FDA Link 01/2020 - 11/2002
3	Amyloid (Amyloid Fibrils)IBA 01/2022 - 08/2011
3	Dopamine (Intropin)FDA LinkGeneric 03/2018 - 09/2009
3	Molecular Chaperones (Chaperone, Molecular)IBA 12/2012 - 08/2004
2	ApolipoproteinsIBA 01/2022 - 01/2020
2	Apolipoprotein E4IBA 01/2022 - 01/2020
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2020 - 11/2015
2	Protein AggregatesIBA 01/2017 - 02/2013
2	Peptides (Polypeptides)IBA 01/2017 - 08/2011
2	Biomarkers (Surrogate Marker)IBA 01/2016 - 01/2016
2	Proteasome Endopeptidase Complex (Proteasome)IBA 10/2011 - 03/2011
2	UbiquitinIBA 10/2011 - 03/2011
1	Cathepsin BIBA 06/2022
1	Adenosine Triphosphate (ATP)IBA 01/2021
1	Sirtuin 3IBA 01/2020
1	Apolipoproteins E (ApoE)IBA 01/2020
1	Apolipoprotein E2IBA 01/2020
1	Apolipoprotein E3IBA 01/2020
1	SirtuinsIBA 01/2020
1	Galectin 3 (LGALS3)IBA 01/2017
1	Superoxide Dismutase-1IBA 01/2016
1	Protein Isoforms (Isoforms)IBA 12/2015
1	sarkosylIBA 12/2015
1	Pharmaceutical PreparationsIBA 05/2015
1	Presenilin-1IBA 07/2014
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2014
1	2- fluoro- 6- (tetrahydrofuran- 3- ylamino)- 4- (3,6,6- trimethyl- 4- oxo- 4,5,6,7- tetrahydro- 1H- indol- 1- yl)benzamideIBA 01/2014
1	Contrast MediaIBA 10/2013
1	Glucosylceramidase (Glucocerebrosidase)IBA 07/2011
1	ElementsIBA 01/2011
1	Tyrosine (L-Tyrosine)FDA Link 11/2009
1	Serine (L-Serine)FDA Link 11/2009
1	Sirtuin 2IBA 07/2007
1	StaurosporineIBA 04/2006
1	Oxidopamine (6 Hydroxydopamine)IBA 04/2006
1	Amyloid beta-PeptidesIBA 08/2005

Therapy/Procedure

3	Therapeutics 05/2015 - 04/2008